Interference of bacterial metabolism by Chelating agents
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Synthetic chelating agents in iron metabolism.
Iron in man is held within the cells incorporated in organic complex molecules, either as functional iron, i.e., hemoglobin and tissue enzymes, or as storage iron, i.e., ferritin and hemosiderin. Owing to the requirements of the erythroid marrow in particular, large amounts of iron must constantly pass from one cell to another through the plasma. This plasma transport is brought about by a #3gl...
متن کاملThe effect of chelating agents on cellular iron metabolism.
1. The effect of iron chelators on iron uptake, ferritin and total protein synthesis was studied in cultured Chang cells. Desferrioxamine depressed ferritin synthesis and completely inhibited iron uptake by ferritin protein. Rhodotorulic acid reduced iron uptake by the cells but had little effect on ferritin synthesis. Diethylenetriamine pentaacetic acid produced complete inhibition of iron upt...
متن کاملDesign of therapeutic chelating agents.
The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes w...
متن کاملThe mechanism of activation of phosphoglucomutase by chelating agents.
Fraenkel-Conrat, H. & Singer, B. (1956). Arch. Biochem. Biophy8. 65, 296. Jagannathan, V. & Luck, J. M. (1949). J. biol. Chem. 179, 569. Koshland, D. E. (1959). In Symposium on the Mechaniam of Enzyme Reactione. J. Gen. (Jomp. Phys. Suppl. 1. Koshland, D. E., Ray, W. J. & Erwin, M. J. (1958). Fed. Proc. 17, 1145. Lowry, C., Keller, P. J. & Taylor, J. F. (1956). Biochim. biophys. Acta, 20, 115. ...
متن کاملAlteration of tissue disposition of cadmium by chelating agents.
The effect of several chelating agents (diethyldithiocarbamic acid, DDC; nitrilotriacetic acid, NTA; 2,3-dimercaptopropanol, BAL; d,l-penicillamine, PEN; 2,3-dimercaptosuccinic acid, DMSA; ethylenediaminetetraacetic acid, EDTA; and diethylenetriaminepentaacetic acid, DTPA) on the toxicity, distribution and excretion of cadmium (Cd) was determined in mice. When chelators were administered immedi...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1959
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.14.105